| Model |
Assay |
Measurements |
| 1. Spared nerve injury-induced neuropathic pain |
1. Hargreaves (focus, local hot pain test) |
Assays 1 and 2: Thermal pain thresholds – hyperalgesia |
| 2. Streptozotocin (STZ)-induced diabetic neuropathy |
2. Hot plate (broader pain test); cold pain |
Assays 3 and 4: Mechanical pain thresholds - allodynia |
| 3. Chemotherapy (e.g. taxol)-induced neuropathy |
3. von Frey hair test |
Assays 5: Measure weight bearing balance - allodynia |
| 4. Reserpine-induced chronic pain accompanied with depression |
4. UGO analgesia meter |
Assays 6: Measure both acute nociceptive pain (early phase) and central sensitization pain (later phase) |
| 5. UVB radiation-induced neuroinflammatory pain |
5. Incapacitance tester |
|
| 6. Electrocutaneous stimulation-induced facial pain |
6. Automated magnetic detection of paw licking, raising or shaking |
|
| 7. Dental inflammatory pain |
|
|
| 8. Incision-induced neuroinflammatory pain |
|
|
| 9. CFA-induced neuroinflammatory pain |
|
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| 10. Formalin-induced inflammatory pain |
|
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