Publications from Afasci Scientists

 

Xinmin (Simon) Xie, MD., PhD.

 

Xie XM, Smart TG.  A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission. Nature (London) 1991;349;521-524.

Xie XM, Steiner SH, Bickel MH.  Kinetics of distribution and adipose tissue storage as a function of lipophilicity and chemical structure.  II. Benzodiazepine.  Drug Metab Dispos 1991;19:15-19.

Smart TG, Moss SJ, Xie XM, Huganir RL.  GABAA receptors are differentially sensitive to zinc: Dependence on subunit composition.  Br J Pharmacol 1991;103:1837-1839.

Xie XM, Smart TG.  g-Hydroxybutyrate hyperpolarizes hippocampal neurons by activating GABAB receptors.  Eur J Pharmacol 1992;212:291-294.

Xie XM, Smart TG.  g-Hydroxybutyrate depresses monosynaptic excitatory and inhibitory postsynaptic potentials in rat hippocampus.  Eur J Pharmacol 1992;223:193-196.

Xie XM, Gerber U, Gähwiler BH, Smart TG.  Interaction of zinc with ionotropic and metabotropic glutamate receptors in rat hippocampal slices.  Neurosci. Lett. 1993;159:46-50.

Xie XM, Smart TG.  Properties of GABA-mediated synaptic potentials induced by zinc in adult rat hippocampal pyramidal neurons.  J Physiol (London) 1993;460:503-523.

Xie XM, Smart TG.  Giant GABAB-mediated synaptic potentials induced by zinc in the rat hippocampus:  Paradoxical effect of zinc on the GABAB receptor.  Eur J Neurosci 1993;5:430-436.

Xie XM, Smart TG.  Long-term potentiation in the hippocampus is modulated by zinc.  Pflügers Arch 1994;427:481-486.

Xie XM, Hider RC, Smart TG.  Modulation of GABA- mediated synaptic transmission by endogenous zinc in the immature rat hippocampus in vitro.  J Physiol (London) 1994;478:75-86.

Krishek* BJ, Xie* XM, Blackstone C, Huganir RL, Moss SJ, Smart TG.  Regulation of GABAA receptor function by protein kinase C phosphorylation.  Neuron 1994;12:1081-1095.  (*These two authors contributed equally to the study.)

Xie XM, Lancaster B, Peakman T, Garthwaite J.  Interaction of the antiepileptic drug lamotrigine with recombinant rat brain type IIA Na+ channels and with native Na+ channels in rat hippocampal neurons.  Pflügers Arch. 1995;430:437-446.

Xie XM, Garthwaite J.  State-dependent inhibition of Na+ currents by the neuroprotective agent 619C89 in rat hippocampal neurons and in a mammalian cell line expressing rat brain type IIA Na+ channels. Neuroscience 1996;73:951-962.

Trezise DJ, John VH, Xie XM.  Voltage- and use-dependent inhibition of Na+ channels in rat sensory neurons by the novel antihypersensitivity agent 4030W92.  Br J Pharmacol 1998;124:953-963.

Dupere JRB, Dale TJ. Starkey SJ, Xie XM.  The anticonvulsant BW534U87 depresses epileptiform activity in rat hippocampal slices by an adenosine-dependent mechanism and through inhibition of voltage-gated Na+ channels.  Br J Pharmacol 1999;128:1011-1020. PMCID: PMC1571724

Clare JJ, Dale TJ, Xie XM, Peakman TC, Chen Y.  Cloning and functional analysis of the type III Na+ channel from human brain.  Ann NY Acad Sci 1999;868:80-83.

Chen YH, Dale TJ, Romanos MA, Whitaker WRJ, Xie XM, Clare JJ.  Cloning distribution and functional analysis of the type III sodium channel from human brain.  Eur. J. Neurosci. 2000;12:4281-4289.

Xie XM, Dale TJ, John VJ, Cater CH, Peakman TC, Clare JJ.  Electrophysiological and pharmacological properties of the human brain type IIA Na+ channel expressed in a mammalian cell line.  Pflügers Arch 2001;441:425-433.

Burbidge SA, Dale TJ, Powell AJ, Whitaker WR, Xie XM, Romanos MA, Clare JJ.  Molecular cloning, distribution and functional analysis of the NAV1.6. voltage-gated sodium channel from human brain.  Brain Res Mol Brain Res 2002;103:80-90.

Ruby NF, Brennan TJ, Xie XM, Cao V, Franken P, Heller HC, O’Hara BF.  The role of melanopsin in circadian responses to light.  Science 2002;298:2211-2213.

Xie XM, Dumas T, Tang L, Brennan T, Reeder T, Thomas W, Klein R, Flores J, O’Hara BF, Heller HC, Franken P.  Lack of the alanine-serine-cysteine transporter 1 causes tremors, seizures and early postnatal death in mice. Brain Res 2005, 1052:212-221.

Quik M, Chen L, Parameswaran N, Xie XM, Langston JW, Sarah E. McCallum SE.  Chronic oral nicotine normalizes dopaminergic function and synaptic plasticity in MPTP-lesioned primates. J Neurosci 2006;26: 4681-4689

Xie XM, Crowder TL, Yamanaka, A, Morairty SR, LeWinter RD, Sakurai T, Kilduff TS.  GABAB receptor-mediated modulation of hypocretin/orexin neurones in mouse hypothalamus. J Physiol 2006;574.2:399–414. PMCID: PMC1817779

Flores AE, Flores JE, Deshpande H, Picazo JA, Xie XM, Franken P, Heller HC, Grahn DA, O'Hara BF., Pattern recognition of sleep in rodents using piezoelectric signals generated by gross body movements. IEEE Trans Biomed Eng. 2007, 54:225-33.

Xie XM, Van Deusen AL, Vitko I, Barrett PQ, Huynh N, Cheng H, Yang N, Edward Perez-Reyes E. Validation of high throughput screening assays against three subtypes of Cav3 T-type channels using molecular and pharmacologic approaches. Assay and Drug Development Technologies 2007;5.2:191-203. PMID: 17477828

Xie XM, Wisor, J, Hara, J, Crowder, T, LeWinter, R, Khroyan, TV, Yamanaka, A, Diano, S, Horvath, T, Sakurai, T, Lawrence Toll, T. & Kilduff, TS. Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia. J Clinical Investigation. 2008;118:2471-24 PMCID2423866

Sonmez K, Zaveri NT, Kerman IA, Burke S, Neal CR, Xie XM, Watson SJ, Toll L. Evolutionary sequence modeling for discovery of peptide hormones. PLoS Comput Biol 2009;5(1): e1000258. PMCID2603333

Hara, J, Gerashchenko, D, Wisor, J, Sakurai, T, Xie XM, Kilduff, T.S.  Thyrotropin-releasing hormone increases behavioural arousal through modulation of hypocretin/orexin neurons. J Neurosci 2009,29(12):3705-14 PMCID: PMCID:2712668

Zhou, W., Madrid, P., Fluitt, A., Andreas Stahl, A.S., and Xie, X.M. Development and validation of a high-throughput screening assay for human long-chain fatty acid transport proteins 4 and 5. J. Biomolecular Screening 2010, 15(5):488-97. PMCID: PMC2887688

Gerashchenko, D., Horvath, T.L., and Xie, X.M. Direct inhibition of hypocretin/orexin neurons in the lateral hypothalamus by nociceptin/orphanin FQ blocks stress-induced analgesia in rats, Neuropharmacology (2011) 60(4):543-9. PMCID: PMC3031765

Reviews and Book Chapters

Haas HL, Greene RW, Heimrich B, Xie XM. (1988)  Long-term potentiation in slices from human hippocampus. In Synaptic plasticity in the hippocampus, Haas H.L. and Buzsaki, G. eds Spring-Verlag, Berlin, PP.77-80. 

Smart TG, Xie XM, Krishek BJ. (1994)  Modulation of inhibitory and excitatory amino acid receptor ion channels by zinc. Progress in Neurobiology 42, 393-439.

Xie, XM, Hagan RM. (1998)  Cellular and molecular actions of lamotrigine: Possible mechanisms of efficacy in bipolar disorder. Neuropsychobiology. 38,119-130.

Kilduff TS, Morairty SR, Steininger TL, Xie XM. (2007)  Hypocretin, GABAB receptors and sleep.  In Narcolepsy and Hypersomnia, Bassetti, C, Billiard M, and Mignot E, eds. New York: Marcel Dekker, Inc. pp. 375-386.

Xie XM, Pardi D, Black J. (2007)  Molecular and cellular actions of γ-Hydroxybutyric acid (GHB): Possible mechanisms underlying GHB efficacy in narcolepsy.  In Narcolepsy and Hypersomnia, Bassetti, C, Billiard M, and Mignot E, eds. New York: Marcel Dekker, Inc. pp. 583-620.

Kilduff TS, Hara, J, Sakurai, T, Xie XM. (2010)  Afferent control of the Hypocretin/orexin neurons. Bassetti, C, et al., eds. Humana Press, Springer (in press)

Patents

Burbidge S, Clare JJ, Cox B, Dupere JRB, Hugan R, Xie XM. (2001) New uses for potassium channel openers. (GlaxoWellcome) PCT Int. Appl. 14pp. WO 0101970 A2 20010111

Allen KD, Kirk CJ, Brennan TJ, Xie XM. (2002-2005) Five non-provisional patent applications on novel utilities of gene filed by Deltagen, Inc.

Xie, XM (2010) Method for treating localized pain. Provisional patent application (Application Number: 61/400,919) filed by AfaSci, Inc.

Shao, X and Xie, XM (2010) Methods and Devices for Nicotine Delivery to Rodents with Lung Alveolar Region-Targeted Aerosol Technology. Provisional patent application (Application Number: 61/418304) filed by AfaSci, Inc and UCLA.

 

Bende Zou, MD., PhD.

 

1.    Zou, B.D., Chen, Y.Z., Wu, C.H., Zou, P.A. (2000). Blockade of U50488H on sodium currents in acutely isolated mice hippocampal CA3 pyramidal neurons. Brain Research, 855,132-136

2.     Zou B.D., Ou-Yang, K.F., Chen, Y.Z., Zou, P.A., Wu, C.H. (2001). Blockade of U50488H on potassium currents in acutely isolated mice hippocampal CA3 pyramidal neurons. Brain Research, 897,52-59

3.    Zou, B.D., Golarai, G., Connor, J.A., Tang, A.C. (2001). Adult long term potentiation is enhanced and sensitized to modulation by corticosterone after neonatal exposure to novel environment. Developmental Brain Research, 130,1-7

1.    Tang, A*., Zou, B.D.* (2002). Neonatal exposure to novelty enhances long term potentiation in CA1 of the rat hippocampus. Hippocampus,  12,398-404

2.    Fan, Y. , Zou, B.D., Ruan, Y.W., Pang, Z.P., Xu, Z.C. (2005). In vivo demonstration of a late depolarizing postsynaptic potential in CA1 pyramidalneurons. Journal of Neurophysiology, 93,1326-35, (*equal contributor)

3.    Zou, B.D., Li, Y., Deng, P., Xu,Z.C. (2005). Alterations of potassium currents in ischemia-vulnerable and ischemia-resistant neurons in the hippocampus after ischemia. Brain Research, 1033,78-89

4.    Ruan, Y.W., Zou, B.D., Fan, Y., Li, Y., Lin, N., Zeng, Y.S., Gao, T.M., Yao, Z.B., Xu, Z.C. (2006). Dendritic plasticity of CA1 pyramidal neurons after transient global ischemia. Neuroscience,140,191-201

5.    Tang, A.C., Zou, B.D., Reeb, B.C., Connor, J.A. (2007). An epigenetic induction of a right-shift in hippocampal asymmetry: selectivity for short- and long-term potentiation but not post-tetanic potentiation.  Hippocampus, 18,5-10

6.    Ruan, Y.W. , Zou, B.D., Fan, Y., Li. Y., Lin, N., Zhang, Y.C., Xu, Z. C.  (2007). Morphological heterogeneity of CA1 pyramidal neurons in response to ischemia.  Journal of Neuroscience Research, 85,193-204

7.    Wang, X.D., Ratnam, J., Zou, B.D., England, P.M. and Basbaum, A.I. (2009). TrkB signaling is required for both the induction and maintenance of tissue and nerve injury-induced persistent pain. Journal of Neuroscience,29,5508-15

8.    Zou, B.D., England, P.M. Discreet phases of AMPA receptor trafficking in hippocampal LTP. (in preparation)

9.    Zou, B.D., Ratnam, J.,  England, P.M. Tracking down the acute role of TrkB in synaptic plasticity. (in preparation)

 

Liya Yang, PhD.

 

1.    Wu FM, Yang L, Zhang XS. Brief review of synaptosomal research.  Chin J Neurosci 1995;2(2): 93-96.

2.    Li J, Wang HR, Yang L, Zhao A, Qiang M, Wu FM. Influence of neural growth factor (NGF) on learning and memory in mice by intrahippocampal injection.  Chin J Neurosci 1995;137

3.    Brosnan RJ, Yang L, Milutinovic PS, Zhao J, Laster MJ, Eger EI, Sonner JM. Ammonia has anesthetic properties. Anesthesia and Analgesia 2007;104(6):1430-1433.

4.    Yang L, Milutinovic PS, Brosnan, RJ, Eger EI, Sonner JM. The plasticizer di (2-ethylhexyl) phthalate modulates gamma-aminobutyric acid type A and glycine receptor function.  Anesthesia and Analgesia 2007;105(2):393-396.

5.    Milutinovic PS*, Yang L*, Cantor RS, Eger EI, Sonner JM. Anesthetic-like modulation of a gamma-aminobutyric acid type A, strychnine-sensitive glycine, and n-methyl-d-aspartate receptors by coreleased neurotransmitters.  Anesthesia and Analgesia 2007;105(2):386-392. *These authors contributed equally to this work.

6.    Yang L, Zhao J, Milutinovic PS, Brosnan RJ, Laster MJ, Eger EI, Sonner JM. Anesthetic properties of the ketone bodies beta-hydroxybutyric acid and acetone.  Anesthesia and Analgesia 2007;105 (3):673-679.

7.    Yang L, Sonner JM. The anesthetic-like effects of diverse compounds on wild-type and mutant gamma-aminobutyric acid type A and glycine receptors. Anesthesia and Analgesia 2008;106(3):838-845.

8.    Yang L, Sonner JM. Anesthetic-like modulation of receptor function by surfactants: a test of the interfacial theory of anesthesia.  Anesthesia and Analgesia 2008;107(3):868-874.

Weng Y, Yang L, Corringer PJ, Sonner JM. Anesthetic sensitivity of the Gloeobacter violaceus proton-gated ion channel. Anesthesia and Analgesia 2010;110 (1):59-63.
 
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